Intrinsic Conflicts of Interest in Clinical Research: A Need for Disclosure


Protection of human subjects from investigators' conflicts of interest is critical to the integrity of clinical investigation. Personal financial conflicts of interest are addressed by university policies, professional society guidelines, publication standards, and government regulation, but "intrinsic conflicts of interest"—conflicts of interest inherent in all clinical research—have received relatively less attention. Such conflicts arise in all clinical research endeavors as a result of the tension among professionals' responsibilities to their research and to their patients and both academic and financial incentives. These conflicts should be disclosed to research subjects and managed as assiduously as are financial conflicts of interest.


Clinical Research

Publication Date


Document Type


Place of Original Publication

Kennedy Institute of Ethics Journal

Publication Information

13 Kennedy Institute of Ethics Journal 83 (2003)

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COinS Sharmon Sollitto Faculty Bio